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Re-exposure of Human Volunteers to a Heterologous Strain of P. Falciparum Sporozoites

NCT01660854 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 21

Last updated 2013-02-13

No results posted yet for this study

Summary

In a previous study (NL33904.091.10) the investigators challenged 24 volunteers after Chloroquine Prophylaxis Sporozoites (CPS) immunization with 45, 30 or 15 infected mosquito-bites respectively. The availability of this immunized cohort opens the unique opportunity to determine protection to a heterologous challenge for both of the protected and unprotected volunteers as the previous challenge infection might have served as immunological boost to the unprotected volunteers.

In the current observational, proof of principle study, the investigators aim to investigate the protection on an individual basis of these previously immunized and challenged volunteers against a heterologous P. falciparum challenge.

Conditions

  • Malaria, Falciparum

Interventions

BIOLOGICAL

Heterologous challenge

challenge by the bites of 5 Plasmodium falciparum infected mosquitoes.

DRUG

Malarone treatment

Three days: 4 tablets 250/100mg per day

Sponsors & Collaborators

  • Leiden University Medical Center

    collaborator OTHER

  • Radboud University Medical Center

    lead OTHER

Principal Investigators

  • RW Sauerwein, PhD · Radboud University Medical Center

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-07-31
Primary Completion
2013-01-31
Completion
2013-01-31

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01660854 on ClinicalTrials.gov