MedTrace Logo

Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil

NCT03106714 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 260

Last updated 2021-03-03

No results posted yet for this study

Summary

The Zika infection is a viral disease that is transmitted to humans by the same mosquito that transmits Dengue and Chikungunya fever. The Zika virus has been found in various body fluids such as urine, blood and semen, but we do not know how long it persists in these fluids. For example, parts of the virus were reported to persist in semen after six months of the onset of symptoms, but we do not know if the virus can stay longer. In this way, we want to investigate how long the Zika virus can be found in other secretions besides blood and urine.

Study Hypothesis: ZIKV can be shed in human body fluids long after the time of the acute infection. Persistence of ZIKV in different body fluids may vary due to the influence of circulating specific ZIKV IgM and IgG, as well as host and environmental factors.

Conditions

  • Zika Virus

Interventions

DIAGNOSTIC_TEST

RT-PCR

Persistence of detectable Zika virus (by RT-PCR test) in all selected body fluids

Sponsors & Collaborators

  • World Health Organization

    collaborator OTHER

  • Ministry of Health, Brazil

    collaborator OTHER_GOV

  • Walter Reed Army Institute of Research (WRAIR)

    collaborator FED

  • Wellcome Trust

    collaborator OTHER

  • National Institute of Allergy and Infectious Diseases (NIAID)

    collaborator NIH

  • Oswaldo Cruz Foundation

    lead OTHER

Principal Investigators

  • Nathalie JN Broutet, MD, PhD · Department of Reproductive Health and Research World Health Organization

  • Ana Maria B de Filippis, PhD · Oswaldo Cruz Foundation (Flavivirus Diagnostic and Reference Laboratory- Rio de Janeiro)

  • Guilherme A Calvet, MD,PhD · Oswaldo Cruz Foundation (Evandro Chagas National Institute of Infectious Diseases- Rio de Janeiro)

  • Rafael FO França, PhD · Oswaldo Cruz Foundation (Research Centre Aggeu Magalhães- Recife)

  • Marcus VG Lacerda, MD,PhD · Tropical Medicine Foundation, Manaus

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-07-21
Primary Completion
2020-06-26
Completion
2020-06-26

Countries

  • Brazil

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03106714 on ClinicalTrials.gov