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Diuretic Testing in Chronic Kidney Disease

NCT06841692 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 86

Last updated 2025-08-07

No results posted yet for this study

Summary

The goal of this clinical trial is to predict the progression of chronic kidney disease by diuretic testing in patients with chronic kidney disease. The main questions it aims to answer are:

Does a worse result of a diuretic test predict the progression of chronic kidney disease?

If there is a comparison group: Researchers will compare the diuretic test in patients with chronic kidney disease to healthy participants to see if the results are different in a healthy kidney.

Participants will undergo diuretic testing. This involves the administration of bumetanide and hydrochlorothiazide with subsequent blood and urine collections.

Conditions

  • Kidney Disease, Chronic

Interventions

DIAGNOSTIC_TEST

Diuretic Testing

The administration of hydrochlorothiazide and bumetanide is used to stimulate and assess tubular function.

Sponsors & Collaborators

Principal Investigators

  • Ewout J. Hoorn, MD, PhD · Erasmus Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-04-01
Primary Completion
2029-10-31
Completion
2029-10-31

Countries

  • Netherlands

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06841692 on ClinicalTrials.gov