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Comparing the Effects of Conivaptan and Diuretics on Plasma Neurohormones and Renal Blood Flow in Patients With Chronic Congestive Heart Failure

NCT00924014 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 8

Last updated 2009-06-18

No results posted yet for this study

Summary

The purpose of the study is to compare the effects of conivaptan and diuretics on renal blood flow and neurohormones.

Conditions

Interventions

DRUG

Conivaptan

Conivaptan 20 mg IV bolus followed by a 4 hour infusion at 1.2 mg/hr

DRUG

Furosemide

Furosemide will be given IV at the subjects usual oral dose up to 80 mg. If the dose is 80 mg or more only 1/2 the dose will be given IV.

DRUG

Conivaptan and furosemide

Furosemide bolus first; conivaptan 20 mg IV bolus/infusion at 1.2 mg/hour for a total of 4 hours

Sponsors & Collaborators

  • Astellas Pharma Inc

    collaborator INDUSTRY

  • Hennepin County Medical Center, Minneapolis

    lead OTHER

Principal Investigators

  • Steven R Goldsmith, MD · Hennepin County Medical Center, Minneapolis

Study Design

Allocation
RANDOMIZED
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-07-31
Primary Completion
2009-12-31
Completion
2010-03-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00924014 on ClinicalTrials.gov