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Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis

NCT01690039 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 170

Last updated 2018-10-09

No results posted yet for this study

Summary

Purpose

1. To compare the performance of the two currently employed urinary acidifications tests in stone formers, the furosemide/fludrocortisone and ammonium chloride loading test.
2. To study the impact of polymorphisms in the genes ATP6V1B1, ATP6V0A4 and SLC4A1 on urinary acidification in stone formers.

Conditions

  • Acidosis, Renal Tubular
  • Nephrolithiasis
  • Vacuolar Proton-Translocating ATPases

Interventions

DRUG

Furosemide-Fludrocortisone-Test (test for urinary acidification)

The presence of a lack of urinary acidification will be assessed by an appropriate test in all patients.

Sponsors & Collaborators

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Daniel Fuster, Attending physician Nephrology · Department of Nephrology and Hypertension, Bern University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-09-30
Primary Completion
2016-12-31
Completion
2017-05-12

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01690039 on ClinicalTrials.gov