UK Research and Innovation has announced major changes to grant funding, with pauses and cuts affecting medical, biological and physical research. The uncertainty has raised concern over curiosity-driven research, staffing and the system’s tolerance for failure.
Proteolysis-targeting chimeras (PROTACs) are advancing from experimental to clinical-stage cancer therapies, with first candidates entering Phase III trials. The technology degrades target proteins rather than blocking them, offering new options for previously undruggable targets.
Researchers have identified how the MYC protein helps pancreatic cancer evade immune detection, while a separate team discovered methods to permanently switch off cancer genes in leukemia through epigenetic therapy targeting Menin and DOT1L proteins.
An international research team has identified antibody 007, which targets HIV-1's V3 glycan site without depending on sugar structures the virus frequently alters, remaining effective against resistant variants and enhancing combination therapies.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07108049 |
Strengthening Relationships and Mental Health Through a Couples-Based Economic Empowerment Intervention |
RECRUITING | NA |
| NCT06993415 |
Optimize Risk Prediction After Myocardial Infarction: The ORACLE Study |
RECRUITING | |
| NCT06960226 |
Replication Study: Reducing Pain With Focused Music Listening |
COMPLETED | NA |
| NCT06841692 |
Diuretic Testing in Chronic Kidney Disease |
RECRUITING | NA |
| NCT06793839 |
3D Contrast Enhanced Acoustic Perfusion Imaging in Adult After Subarachnoid Hemorrhage |
RECRUITING | NA |
| NCT06205160 |
Evaluation of New Flexible High-density Intra-operative ECoG Electrodes for Epilepsy Surgery. ( EpiGrid ) |
RECRUITING | NA |
| NCT06121206 |
Effects of Altitude-like Cognition Training on Neuroplasticity and Cognitive Functions |
COMPLETED | NA |
| NCT06068322 |
Supramaximal High-Intensity Interval Training in People With and Without Chronic Obstructive Pulmonary Disease |
RECRUITING | NA |
| NCT05818345 |
Pricing Interventions Based on Energy Content in Restaurants |
TERMINATED | NA |
| NCT05698862 |
Mapping the Impact of Gut Microbiota on Brain and Behavior Through the Lens of GABA |
RECRUITING | NA |
