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PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest

NCT06836830 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 600

Last updated 2025-08-06

No results posted yet for this study

Summary

Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.

Conditions

  • Ventilation Therapy
  • PEEP, Occult
  • CPR
  • Cardiac Arrest (CA)

Interventions

PROCEDURE

PEEP 5 mbar

Positiv-End-Expiratory Pressure

PROCEDURE

ZEEP 0 mbar

Zero-End-Expiratory Pressure

Sponsors & Collaborators

  • Muehlenkreiskliniken, MKK

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-01
Primary Completion
2026-06-30
Completion
2026-10-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06836830 on ClinicalTrials.gov