Blood Pressure and OXygenation Targets After OHCA

Summary

This study compares two blood pressure targets and two oxygenation targets in the post-resuscitation care of comatose out-of-hospital cardiac arrets patients. Using a novel method the blood pressure-intervention is double-blinded. The oxygenation-intervention is open-label. As a subordinate study, the patients will be randomized 1:1 to active fever-control with an automated feedback temperature control-device for 36 or 72 hours following return of spontaneous circulation.

Conditions

• Out-of-Hospital Cardiac Arrest
• Blood Pressure
• Hemodynamic Instability

Interventions

OTHER

Low normal MAP

The patients are randomized to recieve a Phillips M1006B blood pressure measuring module, offset by +10 %. All patients will target a MAP of 70, but due to the offset module, the patients will target an actual blood pressure of 63 mmHg.

OTHER

High normal MAP

The patients are randomized to recieve a Phillips M1006B blood pressure measuring module, offset by -10 %. All patients will target a MAP of 70, but due to the offset module, the patients will target an actual blood pressure of 77mmHg.

OTHER

Low normal PaO2.

The patients are randomized to a PaO2 target of 9-10 kPa (open-label).

OTHER

High normal PaO2

The patients are randomized to a PaO2 target of 13-14 kPa (open-label).

Sponsors & Collaborators

• Odense University Hospital

  collaborator OTHER

• Jesper Kjaergaard

  lead OTHER

Principal Investigators

• Jesper Kjaergaard, Md, DMSc · Rigshospitalet, Denmark

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

FACTORIAL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-03-10

Primary Completion

2021-12-15

Completion

2022-03-15

Countries

• Denmark

Study Locations