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The Sinonasal Microbiome

NCT06822725 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 285

Last updated 2026-02-02

No results posted yet for this study

Summary

Chronic rhinosinusitis is an inflammatory disease of the sinonasal mucosa with significant impact and limited treatment options. Chronic rhinosinusitis (CRS) poses an important public health problem and causes a large impact on individual quality of life. Studies of CRS have been limited by access to tissue, the complexity of the sinonasal physiology, a lack of available biomarkers, the absence of useful animal models, a paucity of cohorts with biological samples for analysis, and limited well-designed clinical trials or investigations of immune function. Therefore, novel strategies for identifying biological mechanisms underlying this disease are in great need.

Using prospective samples from well characterized subjects, the investigators intend to profile the mucosa associated-bacteria in the nose and sinuses. In parallel, using sinus tissue from patients undergoing surgery, the site will interrogate the epithelium for mucosal immune function to understand host-microbe interaction. This study hypothesizes that the microbial profile of the sinuses initiates an immune responses which leads to chronic inflammation in susceptible people. This study would provide the first comprehensive data on what bacteria are present in the nose and sinus and could lead to important knowledge useful in sinonasal disease.

Conditions

  • Sinonasal Disorder
  • Chronic Rhinosinusitis (Diagnosis)

Interventions

OTHER

Control Group

normals without allergy, those with perennial allergic rhinitis

PROCEDURE

Chronic rhinosinusitis (CRS) with and without Nasal Polyposis

Those with and without nasal polyps, and those with acute exacerbations

Sponsors & Collaborators

  • University of Chicago

    lead OTHER

Principal Investigators

  • Jayat Pinto, MD · University of Chicago

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-13
Primary Completion
2029-01-31
Completion
2029-01-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06822725 on ClinicalTrials.gov