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Investigate the Role of microRNA in Chronic Rhinosinusitis From DC-Th Axis

NCT02325596 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 70

Last updated 2014-12-25

No results posted yet for this study

Summary

This study aimed to evaluate the upstream events of Th17/Treg imbalance in CRS and their immune regulatory factors. Then the investigators aimed to explore the regulatory role of miRNA on DC-Th axis and its dysfunction in the pathogenesis of CRS, in order to determine the miRNA expression profile in CRS and clarify the role of miRNA in the pathogenesis of CRS by regulating the DC-Th axis.

Conditions

  • Rhinosinusitis

Interventions

GENETIC

miRNA mimics or inhibitors

DCs are transfected by the miRNA mimics or inhibitors after they are separated from peripheral blood mononuclear cells in CRS patients

Sponsors & Collaborators

  • First Affiliated Hospital of Chongqing Medical University

    lead OTHER

Principal Investigators

  • Guo-hua Hu HG Guo-hua Hu, MD · First Affiliated Hospital of Chongqing Medical University

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-07-31
Primary Completion
2015-07-31
Completion
2016-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02325596 on ClinicalTrials.gov