Avocado and Postprandial Responses

Summary

The purpose of this study is to see how adding avocado to a breakfast meal affects blood sugar control and signals of hunger and fullness after eating.

The investigators will test the effects of 3 breakfast meals on blood sugar control and signals of hunger and fullness after eating:

1. Whole-wheat bread and strawberry jam
2. Whole-wheat bread, strawberry jam, and avocado
3. Whole-wheat bread and strawberry jam (meal enriched with fat and fiber to mimic that of an avocado)

Participants will undergo 3 test periods, each separated by a week. Each test period consists of one day with set meals that the investigators will provide (breakfast, lunch, and dinner), and then the next morning, participants will eat a breakfast meal and have blood drawn several times over 4 hours.

Conditions

• Healthy
• Healthy Volunteer
• Healthy Volunteers
• Healthy Adult
• Healthy Male and Female Subjects
• Healthy Subjects
• Healthy Volunteers Only
• Healthy Non-smokers

Interventions

OTHER

Negative control

Participants will be given a breakfast meal with 76 grams of bread and 60 grams of jam per 2000 daily calories.

OTHER

Avocado

Participants will be given a bread and jam breakfast (76 grams of bread and 60 grams of jam per 2000 daily calories) supplemented with 84 grams of avocado per 2000 daily calories.

OTHER

Fat and fiber addition

Participants will be given a bread and jam breakfast (76 grams of bread and 60 grams of jam per 2000 daily calories) supplemented with 13 grams of fat (mix of high-oleic safflower oil, safflower oil, palm oil, and macadamia nut oil) and 5.5 grams of fiber (mix of cellulose and pectin) per 2000 daily calories.

Sponsors & Collaborators

• Avocado Nutrition Center

  collaborator UNKNOWN

• University of Vermont Medical Center

  lead OTHER

Principal Investigators

• Jana Kraft, Ph.D. · University of Vermont

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

21 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2025-03-31

Primary Completion

2026-02-28

Completion

2026-06-30

Countries

• United States

Study Locations