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Noninvasive Ventilation Breathing Test Guiding Weaning in Patients With Acute Hypoxic Respiratory Failure

NCT06574659 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 160

Last updated 2026-05-14

No results posted yet for this study

Summary

SBT, as a routine extubation strategy for invasive mechanical ventilation, has been widely recognized. However, in recent years, studies have found that SBT may lead to delayed extubation, which has been confirmed in COPD patients but has not yet been widely accepted in patients with acute hypoxic respiratory failure. Both invasive mechanical ventilation and non-invasive mechanical ventilation are positive pressure ventilation, with the essential difference being the human-machine interface. The safe inspiratory pressure for non-invasive mechanical ventilation should not exceed 20cmH2O (1cmH2O=0.098 kPa). If the cause of respiratory failure is relieved or removed, respiratory function improves, and the patient has good airway protection ability and can tolerate non-invasive ventilation, the endotracheal tube can be removed as soon as possible to switch to non-invasive mechanical ventilation, thereby shortening the time of invasive mechanical ventilation and reducing the risk of complications. This study trial aims to identify the timing of early extubation sequential non-invasive mechanical ventilation in patients with acute hypoxic respiratory failure through non-invasive ventilation breathing tests, providing a basis for updating the process of invasive mechanical ventilation extubation.

Conditions

  • Acute Hypoxic Respiratory Failure

Interventions

PROCEDURE

Noninvasive ventilation breathing test guiding sequential invasive Ventilation and noninvasive ventilation weaing protocol

Noninvasive ventilation breathing test guiding sequential invasive Ventilation and noninvasive ventilation weaing protocol

PROCEDURE

The standard SBT guiding weaning group

The standard SBT guiding weaning protocol

Sponsors & Collaborators

  • Sichuan University

    collaborator OTHER

  • Dazhou Central Hospital

    collaborator OTHER

  • West China Hospital

    lead OTHER

Principal Investigators

  • Yan Kang · Department of Critical Care Medicine

  • Yongfang Zhou · Department of Respiratory Care

  • Xiaoyi Liu · Department of Critical Care Medicine

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-08-03
Primary Completion
2025-03-20
Completion
2025-03-20

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06574659 on ClinicalTrials.gov