MedTrace Logo

Characterization of Patients With Cardiomyopathy to Identify Critical Patients Candidates for Cardiac Transplantation

NCT06813443 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 700

Last updated 2025-02-07

No results posted yet for this study

Summary

The study aims to identify new diagnostic and prognostic markers for CMP that can help predict disease progression. In particular, the study will focus on microRNAs (miRNAs) and spatial transcriptomics, which are emerging techniques that may provide insights into the underlying disease mechanisms. By understanding these markers, the investigators hope to improve the way the investigators diagnose and manage CMP, particularly in terms of predicting progression to heart failure or heart transplantation.

The study will evaluate patients with hypertrophic cardiomyopathy (e.g., sarcomeric forms, Anderson-Fabry disease, AL, and TTR cardiac amyloidosis), dilated cardiomyopathy and arrhythmogenic cardiomyopathy. These patients will undergo clinical evaluations, including ECG, echocardiograms, CMR, biopsy analysis, and genetic testing, as well as molecular studies such as transcriptomics and miRNA analysis. This comprehensive approach aims to identify potential new biomarkers for diagnosing and predicting the disease course.

Conditions

  • Cardiomyopathies
  • Amyloidosis Cardiac
  • Fabry Disease
  • Arrhythmogenic Cardiomyopathy
  • Hypertrophic Cardiomyopathy (HCM)
  • Laminopathies
  • Dystrophia Myotonica
  • Mitochondrial Cardiomyopathy
  • Dilated Cardiomyopathy
  • Sudden Cardiac Death
  • Heart Transplantation
  • Glycogen Storage Disease
  • Infiltrative Cardiomyopathy
  • Cardiac Magnetic Resonance Imaging
  • Electrocardiogram
  • Micro RNA
  • Echocardiogram

Sponsors & Collaborators

  • IRCCS Azienda Ospedaliero-Universitaria di Bologna

    lead OTHER

Principal Investigators

  • Elena Biagini, MD, PhD · IRCCS Azienda Ospedaliero-Universitaria

Eligibility

Min Age
12 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-13
Primary Completion
2027-06-30
Completion
2027-12-14

Countries

  • Italy

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06813443 on ClinicalTrials.gov