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Non Invasive Detection of Cardiac Allograft Rejection by Circulating microRNAs

NCT02672683 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 461

Last updated 2025-11-20

No results posted yet for this study

Summary

The purpose of this study is to evaluate the level of expression of 4 circulating microRNAs in the serum using RT-PCR. A pilote study with cardiac transplant patients has shown that expression of these microRNAs could discriminate patients with a histologically proven rejection from patient displaying a normal endomyocardial biopsy. The signature must be confirmed in unselected patients and its stability evaluated according to clinical, biological and immunological parameters of included patients.

Conditions

  • Cardiac Transplantation

Sponsors & Collaborators

  • URC-CIC Paris Descartes Necker Cochin

    collaborator OTHER

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Principal Investigators

  • Jean-paul Duong Van Huyen, MD, PhD · Necker Hospital, AP-HP

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-09-26
Primary Completion
2017-04-20
Completion
2019-03-26

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02672683 on ClinicalTrials.gov