A Study on the Efficacy of Atezolizumab Combined with Chemotherapy
NCT06780826 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1430
Last updated 2025-01-17
Summary
This is a multicenter phase III simulated RCT study aimed to compare the efficacy and safety of atezolizumab combined with chemotherapy versus placebo combined with chemotherapy in small cell lung cancer.
Conditions
- Lung Cancer, Small Cell
Interventions
- DRUG
-
Atezolizumab, 1200 mg intravenous infusion, 21 days per cycle
- DRUG
-
Etoposide
Etoposide,intravenous infusion, 100mg/m,21 days per cycle
- DRUG
-
carboplatin,intravenous infusion, AUC=5, 21 days per cycle.
Sponsors & Collaborators
-
Shanghai Pulmonary Hospital, Shanghai, China
lead OTHER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-08-28
- Primary Completion
- 2025-06-30
- Completion
- 2025-09-30
Countries
- China
Study Locations
More Related Trials
-
A Phase III Study to Investigate Efficacy and Safety of HLX10 + Chemotherapy in Patients With ES-SCLC
NCT04063163 ·Status: COMPLETED ·Phase: PHASE3
-
Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)
NCT05224141 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Study of Atezolizumab Compared With Docetaxel in Non-Small Cell Lung Cancer (NSCLC) After Failure With Platinum-Containing Chemotherapy
NCT02813785 ·Status: COMPLETED ·Phase: PHASE3
-
Testing the Addition of a New Immunotherapy Drug, Atezolizumab (MPDL3280A), to the Usual Chemoradiation (CRT) Therapy Treatment for Limited Stage Small Cell Lung Cancer (LS-SCLC)
NCT03811002 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Study of Atezolizumab (MPDL3280A) Compared With a Platinum Agent (Cisplatin or Carboplatin) + (Pemetrexed or Gemcitabine) in Participants With Stage IV Non-Squamous or Squamous Non-Small Cell Lung Cancer (NSCLC) [IMpower110]
NCT02409342 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Platinum Plus Etoposide With or Without Tislelizumab in Participants With Untreated Extensive-Stage Small Cell Lung Cancer
NCT04005716 ·Status: COMPLETED ·Phase: PHASE3
-
PD-L1/PD-1 Inhibitors Plus Chemotherapy Versus Chemotherapy Alone for the Neoadjuvant Treatment of Limited-stage SCLC
NCT06375109 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Study of Atezolizumab in Combination With Carboplatin + Paclitaxel or Carboplatin + Nab-Paclitaxel Compared With Carboplatin + Nab-Paclitaxel in Participants With Stage IV Squamous Non-Small Cell Lung Cancer (NSCLC) [IMpower131]
NCT02367794 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Atezolizumab in Combination With Carboplatin Plus (+) Paclitaxel With or Without Bevacizumab Compared With Carboplatin+Paclitaxel+Bevacizumab in Participants With Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
NCT02366143 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Atezolizumab Plus Carboplatin and Etoposide With or Without Tiragolumab in Patients With Untreated Extensive-Stage Small Cell Lung Cancer
NCT04256421 ·Status: COMPLETED ·Phase: PHASE3
-
The Study is Being Conducted to Evaluate the Efficacy and Safety of SHR-1316 in Combination With Chemo-radiotherapy in Patients With LS-SCLC.
NCT04691063 ·Status: UNKNOWN ·Phase: PHASE3
-
Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer
NCT06712355 ·Status: RECRUITING ·Phase: PHASE3
-
Comparing the Efficacy and Safety of a New Additional Treatment With Tislelizumab in Non-Small Cell Lung Cancer (NSCLC)
NCT04379635 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
SX-682 and Atezolizumab for the Treatment of Advanced or Metastatic, Recurrent Non-small Cell Lung Cancer
NCT07322341 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Study of Atezolizumab Compared With a Single-Agent Chemotherapy in Treatment Naïve Participants With Locally Advanced or Recurrent or Metastatic Non-Small Cell Lung Cancer Who Are Deemed Unsuitable For Platinum-Doublet Chemotherapy
NCT03191786 ·Status: COMPLETED ·Phase: PHASE3
-
Atezolizumab and Rechallenge Chemotherapy in Relapsed Patients With Extensive-stage Small Cell Lung Cancer (ES-SCLC).
NCT06663098 ·Status: RECRUITING ·Phase: PHASE2
-
A Study of Atezolizumab With or Without Tiragolumab Consolidation in Limited Stage Small Cell Lung Cancer
NCT04308785 ·Status: TERMINATED ·Phase: PHASE2
-
Study of Small Doses of Etoposide as Maintenance Treatment in Small Cell Lung Cancer(SCLC)
NCT02179528 ·Status: UNKNOWN ·Phase: PHASE2
-
Atezolizumab Combined With Chemotherapy in Extensive Stage SCLC
NCT04920981 ·Status: COMPLETED
-
Testing the Addition of the Drug Atezolizumab to the Usual Radiation Treatment for Patients With Early Non-small Cell Lung Cancer
NCT04214262 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Pilot Study of PD-1inhibitor (Tislelizumab) Plus Chemotherapy as Neoadjuvant Therapy for Limited-Stage Small-Cell Lung Cancer
NCT04542369 ·Status: RECRUITING ·Phase: PHASE2
-
Neoadjuvant Immunotherapy for Stage III Non-small Cell Lung Cancer
NCT04728724 ·Status: RECRUITING ·Phase: PHASE2
-
Liver Directed RT + Chemo-immunotherapy for ES-SCLC
NCT04923776 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Atezolizumab as Neoadjuvant and Adjuvant Therapy in Resectable Non-Small Cell Lung Cancer (NSCLC) - Lung Cancer Mutation Consortium (LCMC3)
NCT02927301 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Atezolizumab in Combination With Carboplatin or Cisplatin + Pemetrexed Compared With Carboplatin or Cisplatin + Pemetrexed in Participants Who Are Chemotherapy-Naive and Have Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) (IMpower 132)
NCT02657434 ·Status: COMPLETED ·Phase: PHASE3