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Sedation and Guided Education for Depression Study

NCT06705270 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-04-24

No results posted yet for this study

Summary

The goal of this clinical trial is to understand how patient education surrounding a one-time, consciousness-altering medical intervention impacts the antidepressant response to the intervention in adults with major depressive disorder. In this study, the consciousness-altering medical intervention is a single infusion of propofol, an intravenous anesthetic which might have antidepressant properties.

The main question this study aims to answer is: Does the focus of patient education influence the antidepressant response to a single intravenous infusion of propofol?

Researchers will compare response-focused vs. diagnosis-focused education.

Qualifying participants will:

* Undergo a single intravenous infusion of propofol which will induce a temporary state of sedation
* Wear an EEG cap that records brain activity during sedation
* Be randomized to receive either response-focused or diagnosis-focused education about their brain signals after they recover from sedation
* Be asked to fill out surveys about their mood and other measures of well-being before and after treatment

Conditions

  • Major Depressive Disorder (MDD)

Interventions

BEHAVIORAL

Response-focused education

Once participants recover from sedation, they will receive education that is focused on their response to treatment.

BEHAVIORAL

Diagnosis-focused education

Once participants recover from sedation, they will be provided education that is focused on their diagnosis of major depressive disorder.

Sponsors & Collaborators

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-09-30
Primary Completion
2028-09-30
Completion
2028-10-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06705270 on ClinicalTrials.gov