Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study

Summary

The goal of this observational study is to investigate the genetic and epigenetic mechanisms that may contribute to the development of Autism Spectrum Disorder (ASD) in individuals of different age groups. The study aims to explore how genetic variants and environmental factors interact to influence the risk of ASD.

The main questions it aims to answer are:

* Which genetic variants are most strongly associated with the development of ASD?
* How do environmental factors, such as prenatal exposure, influence these genetic risks?
* Can the combination of genetic and epigenetic data improve early detection or intervention strategies for ASD?

Participants will:

* Provide biological samples for genetic and epigenetic analysis.
* Complete detailed questionnaires regarding environmental exposures and family history.
* Participate in clinical assessments to evaluate the severity of ASD symptoms.

Researchers will compare genetic and environmental data between individuals with ASD and those without the disorder to understand how these factors may contribute to the risk of ASD. This multi-center study will take place across several universities and hospitals in Türkiye, focusing on the potential interplay between inherited genetic factors and environmental influences.

Conditions

• Autism Spectrum Disorder (ASD)

Sponsors & Collaborators

• İnvitrotek A.Ş.

  collaborator UNKNOWN

• Konya Selcuk University Faculty of Medicine, Department of Child and Adolescent Psychiatry

  collaborator UNKNOWN

• Konya Selcuk University Faculty of Medicine, Department of Psychiatry

  collaborator UNKNOWN

• Istanbul Cerrahpasa Faculty of Medicine, Department of Child and Adolescent Psychiatry

  collaborator UNKNOWN

• Istanbul Medeniyet University Faculty of Medicine, Department of Child and Adolescent Psychiatry

  collaborator UNKNOWN

• Ankara SBÜ Gülhane Faculty of Medicine, Department of Child and Adolescent Psychiatry

  collaborator UNKNOWN

• Ankara Gazi Faculty of Medicine, Department of Child and Adolescent Psychiatry

  collaborator UNKNOWN

• Izmir Katip Çelebi Faculty of Medicine, Department of Child and Adolescent Psychiatry

  collaborator UNKNOWN

• Şanlıurfa Harran University Faculty of Medicine, Department of Child and Adolescent Psychiatry

  collaborator UNKNOWN

• Erzurum Atatürk University Faculty of Medicine, Department of Child and Adolescent Psychiatry

  collaborator UNKNOWN

• Trabzon Karadeniz Technical University Faculty of Medicine, Department of Child and Adolescent Psychiatry

  collaborator UNKNOWN

• Denizli Pamukkale University Faculty of Medicine, Department of Child and Adolescent Psychiatry

  collaborator UNKNOWN

• Gaziantep University, Department of Child and Adolescent Psychiatry

  collaborator UNKNOWN

• Afyonkarahisar University of Health Sciences, Faculty of Medicine, Department of Child and Adolescent Psychiatry

  collaborator UNKNOWN

• Bursa Uludağ University, Department of Child and Adolescent Psychiatry

  collaborator UNKNOWN

• Giresun University, Department of Child and Adolescent Psychiatry

  collaborator UNKNOWN

• Baskent University

  collaborator OTHER

• Istanbul Medeniyet University, Department of Psychiatry

  collaborator UNKNOWN

• Necmettin Erbakan University

  collaborator OTHER

• Istanbul Çam and Sakura City Hospital, Department of Child and Adolescent Psychiatry

  collaborator UNKNOWN

• Konya Selcuk University Faculty of Medicine, Department of Medical Genetics

  collaborator UNKNOWN

• Research and Treatment Society of Genetic Disorders

  lead OTHER

Principal Investigators

• Ali Torabi, MD.,Ph.D. · Selçuk Üniversitesi Tıp Fakültesi Tıbbi Genetik Anabilim Dalı

• Ali Kandeğer, MD. · RUH SAĞLIĞI VE HASTALIKLARI Uzmanı / Konya Selçuk Üniversitesi Tıp Fakültesi- Ruh Sağlığı ve Hastalıkları Anabilim Dalı Anabilim Dalı

• Ömer Faruk Akça, MD. · Çocuk Ve Ergen Ruh Sağlığı Ve Hastalıkları Uzmanı /Konya Necmettin Erbakan Üniversitesi Tıp Fakültesi- Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Anabilim Dalı

• Nadir Koçak, MD · Tıbbi Genetik Uzmanı / Konya Selçuk Üniversitesi Tıp Fakültesi- Tıbbi Genetik Anabilim Dalı ve Genetik Hastaliklar Araştırma ve Tedavi Derneği(RTSGD) Yönetim kurulu üyesi

• Ebru Marzioğlu Özdemir, MD · Tıbbi Genetik Uzmanı / Konya Selçuk Üniversitesi Tıp Fakültesi- Tıbbi Genetik Anabilim Dalı ve Genetik Hastaliklar Araştırma ve Tedavi Derneği(RTSGD) Yönetim kurulu üyesi

• Özkan Bağcı, Ph.D. · Tıbbi Genetik Uzmanı / Konya Selçuk Üniversitesi Tıp Fakültesi- Tıbbi Genetik Anabilim Dalı ve Genetik Hastaliklar Araştırma ve Tedavi Derneği(RTSGD) Yönetim kurulu üyesi

Eligibility

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2025-12-27

Primary Completion

2027-12-27

Completion

2028-05-27

Countries

• Turkey (Türkiye)

Study Locations