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Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome

NCT06507007 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2026-01-27

No results posted yet for this study

Summary

The goal of this case-control study is to pave the way for new revolutionary treatment measures within hearing loss that could either replace or delay the need for hearing aids. The study focuses on people with Turner syndrome (TS).

The aim is to find out if there are specific DNA methylation patterns and/or RNA expression profiles linked to sensorineural hearing loss (SNHL) in people with TS. Additionally, the structure and function of the inner ear in these individuals will be examined to see if there is a connection to their epigenetic profile.

The main question it aims to answer is: Does epigenetics constitute a common denominator for some of the unexplained SNHL cases?

Turner Syndrome (TS) represents an ideal model for studying epigenetics related to sensorineural hearing loss (SNHL).

Participants will undergo the following tests:

* Ear examinations
* Hearing tests
* Balance tests
* Blood tests
* MRI scans
* CBCT (cone-beam computed tomography) scans

Conditions

  • Sensorineural Hearing Loss
  • Turner Syndrome
  • Inner Ear Disease

Sponsors & Collaborators

  • University of Aarhus

    collaborator OTHER

  • Aarhus University Hospital

    collaborator OTHER

  • Gødstrup Hospital

    lead OTHER

Principal Investigators

  • Therese Ovesen, Prof · University Clinic of Flavour, Balance and Sleep

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-02-01
Primary Completion
2026-06-30
Completion
2027-07-30

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06507007 on ClinicalTrials.gov