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Pharmacokinetics of Oral Calcium Carbonate in Parturients

NCT06650930 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-08-12

No results posted yet for this study

Summary

This study investigates the time course of change in calcium in the blood after a pregnant subject takes an oral dose of calcium carbonate (commonly marketed as "Tums"). Midway through the trial, with IRB permission, the oral calcium formulation was switched to calcium citrate to test whether this, better-absorbed formulation might prove more effective in increasing serum calcium. This information is important for trials investigating whether oral calcium can reduce postpartum hemorrhage, bleeding after delivery.

Conditions

  • Pregnancy
  • Pharmacokinetics
  • Postpartum Hemorrhage

Interventions

DRUG

Oral calcium carbonate

Participants receive a single, open-label dose of oral calcium carbonate 1200mg

DRUG

Oral calcium citrate

Participants receive a single oral dose of calcium citrate 1250mg

Sponsors & Collaborators

Principal Investigators

  • Jessica Ansari, MD, MS · Stanford University

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-01-23
Primary Completion
2025-10-11
Completion
2025-12-03
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06650930 on ClinicalTrials.gov