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Surgical Treatment of Peri-implantitis Using a Bone Substitute With or Without a Resorbable Collagen Membrane

NCT05699343 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 52

Last updated 2026-02-17

No results posted yet for this study

Summary

The objective of the present randomized clinical trial will be to compare two surgical methods of treating peri-implantitis. This study will determine if surgical debridement of peri-implantitis bone defects, including air powder abrasive (APA) decontamination of implant surfaces, in combination with the placement of a bone graft, differs in treatment outcomes compared to placing the same bone graft material with a resorbable collagen membrane placed over the bone graft.

Conditions

  • Peri-Implantitis
  • Surgery

Interventions

PROCEDURE

InterOss Collagen (Bone xenograft) and InterOss Collagen Guide (Collagen membrane)

Group will receive InterOss Collagen and InterOss Collagen Guide during surgical intervention visit.

PROCEDURE

InterOss Collagen (Bone xenograft)

Group will only receive InterOss Collagen during surgical intervention visit.

Sponsors & Collaborators

  • SigmaGraft Inc.

    collaborator UNKNOWN

  • Andrea Ravida

    lead OTHER

Principal Investigators

  • Andrea Ravida, DDS MS PhD · University of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-30
Primary Completion
2028-01-31
Completion
2028-12-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05699343 on ClinicalTrials.gov