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Creating a Global Research Database That Connects Genetic Information and Long-term Health Data to Improve Personalized Treatment for People With Serious Mental Illness

NCT06641726 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 50000

Last updated 2025-10-03

No results posted yet for this study

Summary

This observational study aims to provide new insights into the nature and classification of severe mental illness and dementias that in time should help improve diagnostic practise, and enable the development of new and improved treatments. The investigators will achieve aims by gathering information and biological samples from over 50,000 research participants and then linking this information with participants' electronic health records, genetic and other potential markers of mental illnesses (called biomarkers, derived from biological samples). The investigators will use this resource to analyse how potential risk factors - genetic, other biological and non-biological (related to the participants' life circumstances) - influence participants' experiences, symptoms, and outcomes (both mental and physical health). The investigators will also use advanced analysis to assess whether there may be better ways of grouping together and understanding the experiences of those with severe mental illnesses and dementias. Given the value and importance of this resource for advancing mental health research, the investigators will also make the data available to other researchers to pursue these broad research aims.

Conditions

  • Bipolar Disorder (BD)
  • Schizophrenia Disorders
  • Major Depressive Diorder
  • Dementia

Interventions

OTHER

Not applicable- observational study

This is non-interventional, cross-sectional observational study and thus there is no intervention.

Sponsors & Collaborators

  • Cardiff University

    collaborator OTHER

  • Akrivia Health

    lead INDUSTRY

Principal Investigators

  • Prof. James Walters · Cardiff University

Eligibility

Min Age
18 Years
Max Age
110 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-05-16
Primary Completion
2035-01-01
Completion
2035-07-01

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06641726 on ClinicalTrials.gov