Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies

Summary

The objective of this retrospective observational study is to compare commonly prescribed bipolar disorder medications for their impact on: (1) hospitalization; (2) suicide attempts and self-harm; and (3) risk of drug-induced adverse effects such as kidney disease and diabetes mellitus. In addition, the investigators will examine heterogeneity of treatment effect by co-morbidity within pediatric, adult, and elderly sub-populations. Patient focus groups are convened to elicit additional questions and provide feedback on results.

Conditions

• Bipolar Disorder

Interventions

DRUG

Lithium Carbonate

Exposure to all dosages and delivery forms.

DRUG

Lamotrigine

Exposure to all dosages and delivery forms.

DRUG

Valproic Acid

Exposure to all dosages and delivery forms.

DRUG

Oxcarbazepine

Exposure to all dosages and delivery forms.

DRUG

Carbamazepine

Exposure to all dosages and delivery forms.

DRUG

Ziprasidone

Exposure to all dosages and delivery forms.

DRUG

Risperidone

Exposure to all dosages and delivery forms.

DRUG

Quetiapine

Exposure to all dosages and delivery forms.

DRUG

Olanzapine

Exposure to all dosages and delivery forms.

DRUG

Aripiprazole

Exposure to all dosages and delivery forms.

DRUG

Fluoxetine / Olanzapine

Exposure to all dosages and delivery forms.

DRUG

Haloperidol

Exposure to all dosages and delivery forms.

DRUG

Perphenazine

Exposure to all dosages and delivery forms.

DRUG

Clozapine

Exposure to all dosages and delivery forms.

DRUG

Asenapine

Exposure to all dosages and delivery forms.

DRUG

Lurasidone

Exposure to all dosages and delivery forms.

DRUG

Paliperidone

Exposure to all dosages and delivery forms.

DRUG

Mirtazapine

Exposure to all dosages and delivery forms.

DRUG

Bupropion

Exposure to all dosages and delivery forms.

DRUG

Desvenlafaxine

Exposure to all dosages and delivery forms.

DRUG

Duloxetine

Exposure to all dosages and delivery forms.

DRUG

Venlafaxine

Exposure to all dosages and delivery forms.

DRUG

Citalopram

Exposure to all dosages and delivery forms.

DRUG

Escitalopram

Exposure to all dosages and delivery forms.

DRUG

Fluoxetine

Exposure to all dosages and delivery forms.

DRUG

Fluvoxamine

Exposure to all dosages and delivery forms.

DRUG

Paroxetine

Exposure to all dosages and delivery forms.

DRUG

Sertraline

Exposure to all dosages and delivery forms.

DRUG

Vilazodone

Exposure to all dosages and delivery forms.

DRUG

Doxepin

Exposure to all dosages and delivery forms.

Sponsors & Collaborators

• Patient-Centered Outcomes Research Institute

  collaborator OTHER

• Montana State University

  collaborator OTHER

• National Alliance on Mental Illness Montana

  collaborator UNKNOWN

• CGStat LLC

  collaborator OTHER

• Risk Benefit Statistics LLC

  collaborator INDUSTRY

• National Alliance on Mental Illness New Mexico

  collaborator UNKNOWN

• National Alliance on Mental Illness Westside Los Angeles

  collaborator UNKNOWN

• University of New Mexico

  lead OTHER

Principal Investigators

• Christophe G Lambert, PhD · University of New Mexico Health Sciences Center

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-09-30

Primary Completion

2019-06-30

Completion

2019-06-30

Countries

• United States

Study Locations