An Innovative Master Platform for Clinical Trials in Mood Disorders

Summary

Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several effective treatments exist, it is often difficult to match the right treatment to an individual person. Repeated efforts to find the right treatment contribute to poor functioning, low quality of life, and prolongs the time it takes to get well. Most areas of medicine are able to use 'biomarkers' or clinical tests, blood tests, or imaging to help diagnose and treat illness. The search for biomarkers in mood disorders is advancing, but one roadblock to progress is the lack of large, standardized studies of mood disorders that are needed to accurately identify biomarkers. The aim of the ENABLE platform is to provide the Canadian neuroscience community a standardized way of collecting biomarker data from individuals with a range of mood disorders symptoms. In addition, this 'master clinical trial platform' framework will provide a pool of participants who can be recruited into biomarker-based clinical trials.

Conditions

• Mood Disorders
• Depressive Disorder
• Bipolar and Related Disorders

Sponsors & Collaborators

• Unity Health Toronto

  collaborator OTHER

• Centre for Addiction and Mental Health

  collaborator OTHER

• Queen's University

  collaborator OTHER

• University of Ottawa

  collaborator OTHER

• University of British Columbia

  collaborator OTHER

• University of Calgary

  collaborator OTHER

• McGill University

  collaborator OTHER

• Nova Scotia Health Authority

  collaborator OTHER

• University of Michigan

  collaborator OTHER

• Simon Fraser University

  collaborator OTHER

• University Health Network, Toronto

  collaborator OTHER

• St. Joseph's Healthcare Hamilton

  lead OTHER

Principal Investigators

• Benicio N Frey · St. Joseph's Healthcare Hamilton

Eligibility

Min Age

16 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-10-17

Primary Completion

2026-03-31

Completion

2026-03-31

Countries

• Canada

Study Locations