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Electrophysiological Signature of Mild Cognitive Impairment and Its Relationship with Parkinson's Disease: a High-density EEG Investigation

NCT06640673 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 42

Last updated 2024-10-15

No results posted yet for this study

Summary

The study aims to investigate neural correlate of Mild Cognitive Impairment (MCI) in Parkinson's disease (PD) and to identify a link between functional impairment (in both cognitive and motor domains) and electrophysiological cortical sing of MCI in PD. A sample of 42 subjects will be divide into three subgroup: healthy control, PD with MCI (PD-MCI) and PD without MCI (PD-ctrl). Those subjects will undergo a specific neuropsychological evaluation and, to measure the electro-cortical activity, high-density electroencephalography (hdEEG) will be record during both resting state and cognitive tasks. Furthermore, hdEEG data will be combine with structural magnetic resonance to obtain information about network connectivity.

Conditions

  • Parkinson Disease
  • Parkinson Disease, Mild Cognitive Impairment
  • Healthy

Interventions

DIAGNOSTIC_TEST

Hd-EEG

Subjects undergo a clinical and neuropsychological assesment, then a Hd-EEG both during resting state and execution of tasks, and structural Magnetic Resonance Imaging

Sponsors & Collaborators

  • IRCCS San Camillo, Venezia, Italy

    lead OTHER

Principal Investigators

  • francesca burgio, phd · San Camillo IRCCS

Eligibility

Min Age
50 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-06-18
Primary Completion
2024-12-01
Completion
2025-05-31

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06640673 on ClinicalTrials.gov