Analysis of Cortical Biomarkers for PD

Summary

Previous studies revealed changes in the pattern of cortical electrical activity of patients with Parkinson's disease (PD) and suggested that these changes may be dependent on the phenotypes of the disease and other related factors. A greater understanding of cortical electrical activity in PD patients may be relevant to guide professionals about the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). The present study aims to evaluate the pattern of brain activity of PD patients and to correlate the findings with the disease phenotypes and with other clinical characteristics. For this, volunteers with PD and healthy will participate in a single experimental session in which behavioral and electrophysiological assessments will be performed.

Conditions

• Parkinson Disease
• Healthy

Interventions

OTHER

Parkinson's disease patients

The neurophysiological evaluation will be conducted during "ON" (with medication) and "OFF" (without medication) period, by transcranial magnetic stimulation by single pulse (EMT-p) and by EEG.

OTHER

No drug

The neurophysiological evaluation in healthy subjects will be conducted by transcranial magnetic stimulation by single pulse (EMT-p) and by EEG.

Sponsors & Collaborators

• Universidade Federal de Pernambuco

  lead OTHER

Principal Investigators

• Lívia Shirahige, MsC · Universidade Federal de Pernambuco

• Adriana Maciel, MsC · Universidade Federal de Pernambuco

• Déborah Oliveira, MsC · Universidade Federal de Pernambuco

• Fernanda Nogueira, Bachelor · Universidade Federal de Pernambuco

• Marina Berenguer, Bachelor · Universidade Federal de Pernambuco

• Brenda Valença · Universidade Federal de Pernambuco

• Rodrigo Brito, Bachelor · Universidade Federal de Pernambuco

Eligibility

Min Age

40 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2018-09-01

Primary Completion

2019-01-30

Completion

2020-01-30

Countries

• Brazil

Study Locations