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Mapping the Effect of (neuro)inflammation on Stress Sensitivity in the Brain of Healthy Men

NCT06620679 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2024-10-01

No results posted yet for this study

Summary

The goal of this interventional study is to determine the effects of inflammation on stress responses in the brain of healthy men. In order to achieve this goal, participants are injected with an inflammation-inducing agent, then observed inside a brain scanner.

Conditions

Interventions

BIOLOGICAL

Lipopolysaccharide (LPS)

Lipopolysaccharide (LPS), single i.v. bolus, 0.4 ng/kg body weight

OTHER

Placebo

Normal saline, single i.v. bolus, in equal volume to intervention

Sponsors & Collaborators

  • Universitaire Ziekenhuizen KU Leuven

    lead OTHER

Principal Investigators

  • Lukas Van Oudenhove, MD, PhD · KU Leuven

  • Kristin Verbeke, Pharm, PhD · KU Leuven

  • Boushra Dalile, PhD · KU Leuven

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-05-03
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Belgium

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06620679 on ClinicalTrials.gov