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Inflammation and Brain Function - Main Study

NCT03551184 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 52

Last updated 2018-06-11

No results posted yet for this study

Summary

In this randomized double blind study, 52 healthy participants were injected with either 0.6 ng/kg body weight or placebo to test if changes in pain sensitivity is associated with change in neural activity using BOLD MR scanning.

Conditions

  • Sickness Behavior

Interventions

BIOLOGICAL

Endotoxin

Endotoxin at 0.6 ng/kg of body weight administered intravenously (Escherichia Coli, Lot nr G3E0609, United States Pharmacopeia Rockville, MD)

BIOLOGICAL

Placebo

Saline administered intravenously

Sponsors & Collaborators

  • University of California, San Francisco

    collaborator OTHER

  • The Swedish Society of Medicine

    collaborator OTHER

  • Swedish Heart Lung Foundation

    collaborator OTHER

  • The Swedish Research Council

    collaborator OTHER_GOV

  • Swedish Council for Working Life and Social Research

    collaborator OTHER

  • Stockholm University

    collaborator OTHER

  • Karolinska Institutet

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-10-31
Primary Completion
2011-03-31
Completion
2011-03-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03551184 on ClinicalTrials.gov