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Physiological Responses in Experimentally Induced Cognitive Fatigue in People With Multiple Sclerosis (MS)

NCT05003375 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2021-08-12

No results posted yet for this study

Summary

The current study will add to the current knowledge by combining several electrophysiological techniques to examine the relationship between physiological responses and cognitive fatigue and daily activity performance in a stress- and fatigue-inducing protocol.

The aims of this study are: 1) to evaluate the feasibility and usability of assessing physiological responses in an experimental set-up and 2) to investigate the association between physiological outcomes, experimentally induced stress and cognitive fatigue in people with multiple sclerosis (MS) and healthy controls.

Conditions

Interventions

BEHAVIORAL

High-challenging cognitive protocol to provoke stress and (cognitive) fatigue

Baseline measurement is done in two parts: 1) resting for five minutes (no talking, no movement) and 2) speaking at normal pace (2 minutes). This is immediately followed by a measurement of the physiological response variables during the testing, in which the following protocol is performed in the order presented: 1) SDMT-NBack task-SDMT\*-NBacktask\*\*, 2) NBack task-SDMT-NBack task-SDMT. Participants will run either sequence to check for effects of the previous testing. During the conduct of the study, it will be ensured that half of the participants in each group followed Sequence 1 and the other half of the group followed Sequence 2. During all these measurements, the participant will sit at a table with a computer on which the tests are performed. \*SDMT: Symbol Digit Modalities Test: see description in outcome measures \*\*N-Back Task: see description in outcome measures

Sponsors & Collaborators

  • National MS Center Melsbroek

    collaborator OTHER

  • KU Leuven

    lead OTHER

Principal Investigators

  • Daphne Kos, PhD · KU Leuven

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-10-15
Primary Completion
2021-08-30
Completion
2021-09-01

Countries

  • Belgium

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05003375 on ClinicalTrials.gov