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MicroRNA Profile As a Biomarker of Liver Damage in Different Types of Liver Donors.

NCT06611046 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 28

Last updated 2024-09-24

No results posted yet for this study

Summary

The goal of this observational study is to analyze the expression of liver-derived miRNAs in different types of liver donors to gain in depth knowledge about distinctive physiologic features within donors and find potential biomarkers for graft quality assessment. The main questions it aims to answer are:

Is there a distinctive miRNA profile between donors after brain-stem death and donors after circulatory death?

Is heparinase I treatment necessary to overcome miRNA quantification interference in heparinized liver donor samples ?

Researchers will compare miRNA expression in donors after brain-stem death and donors after circulatory death with I) a subgroup of donors with unusable grafts due to significant steatosis, 2) and with a subgroup of healthy controls undergoing elective cholecystectomy to set the reference miRNA profiles in extreme conditions.

Conditions

  • MicroRNA Profile
  • Liver Transplant
  • Organ Donor

Interventions

OTHER

organ donor

Observational study with sample collection of serum, liver tissue and perfusate fluid from liver donors. No specific interventions were done to the donors as part of the study. The samples were analyzed for specific microNA expression by RT-qPCR. \*Control group: only serum samples were collected from this group.

Sponsors & Collaborators

  • Vall Hebron Insitut Recerca

    collaborator NETWORK

  • Mar Dalmau

    lead OTHER

Principal Investigators

  • Ramon Charco, MD, PhD · Chief of HPB surgery and Transplant Department in Vall d Hebron University Hospital

  • Concepción Gómez-Gavara, MD, PhD · HPB surgery and Liver Transplant consultant in Vall d Hebron University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-10-02
Primary Completion
2021-07-27
Completion
2024-09-01

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06611046 on ClinicalTrials.gov