THC Crossover Study

Summary

This is a randomized, crossover study enrolling experienced dual cannabis-tobacco smokers (N=18) to describe the differences in THC and toxicant exposure, examining pharmacokinetic, subjective, and cardiovascular effects from smoking and vaping dry herb cannabis. This study will also examine the differences in toxicant exposure and cardiovascular disease risk between smoking cannabis and smoking tobacco cigarettes.

Conditions

• THC
• Cannabis
• Cannabis Smoking
• Cannabis Use, Unspecified
• Cigarette Smoking
• Tobacco Use
• Nicotine Dependence
• Nicotine Withdrawal
• Cardiovascular Risk Factor

Interventions

OTHER

Smoked Cannabis

Cannabis will be purchased by the participants and reimbursed the full cost by the study. Participants will be asked to purchase enough to last 2 full days of use. To reduce variability between products, participants will be asked to purchase cannabis from one dispensary near the research facility (Purple Star MD at 2520 Mission St., San Francisco). Receipt must be provided to study staff.

OTHER

Vaped Cannabis

Cannabis will be purchased by the participants and reimbursed the full cost by the study. Participants will be asked to purchase enough to last 2 full days of use. To reduce variability between products, participants will be asked to purchase cannabis from one dispensary near the research facility (Purple Star MD at 2520 Mission St., San Francisco). Receipt must be provided to study staff. All participants will use the study-provided PAX® (PAX 2) dry herb vaporizer, one of the most popular handheld vaporizers.

OTHER

Tobacco Cigarette

Tobacco cigarettes of participants' choice (usual brand) will be provided by research staff for use on the study.

Sponsors & Collaborators

• Tobacco Related Disease Research Program

  collaborator OTHER

• University of California, San Francisco

  lead OTHER

Principal Investigators

• Gideon St. Helen, PhD · University of California, San Francisco

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

21 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-10-30

Primary Completion

2024-06-25

Completion

2024-06-25

Countries

• United States

Study Locations