Understanding the Transition from Normal Melanocytes to Nevus to Melanoma

Summary

The primary objective of this study is to identify the molecular identity profiles of all cellular states that characterize the progression from benign nevi to malignant melanoma in CAYA patients with L/GCMN. The secondary objectives are:

* To longitudinally characterize the cell-free DNA (cfDNA) from CAYA patients.
* To improve the early diagnosis and treatments for intermediate conditions such as L/GCMN through evidence-based interpretation of personal risk from endogenous or exogenous sources.
* To test pre-clinical strategies to best model and improve patient response.

Conditions

• Congenital Melanocytic Nevi
• Melanoma, Skin
• Nevi and Melanomas

Interventions

GENETIC

Methylomics

Methylomics analysis of FFPE blocks and frozen tissues

GENETIC

RNA sequencing

RNA sequencing of FFPE blocks and frozen tissues

GENETIC

Spatial transcriptomics

Spatial transcriptomics of FFPE blocks and frozen tissues

GENETIC

Liquid biopsy

cfDNA characterization extracted from blood/saliva

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France

  collaborator UNKNOWN

• University Hospital Tuebingen

  collaborator OTHER

• University of Florence

  collaborator OTHER

• Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

  collaborator OTHER

• University Of Perugia

  collaborator OTHER

• German Cancer Research Center

  collaborator OTHER

• Karolinska Institutet

  collaborator OTHER

• Maria Sklodowska-Curie National Research Institute of Oncology

  collaborator OTHER

• Institut Curie

  collaborator OTHER

• Medical University of Gdansk

  collaborator OTHER

• Princess Maxima Center for Pediatric Oncology

  collaborator OTHER

• Institut Català d'Oncologia

  collaborator OTHER

• Fundacion Clinic per a la Recerca Biomédica

  lead OTHER

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-01-01

Primary Completion

2026-03-31

Completion

2026-11-30

Countries

• France
• Spain

Study Locations