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Natural History Study of Moles and Suspicious Melanoma

NCT00288938 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2017-07-02

No results posted yet for this study

Summary

Background:

* Melanocytic nevi, or "moles," are non-cancerous growths of a type of skin cell called a melanocyte.
* Large congenital melanocytic nevi (LCMN) are a special type of mole that begins to grow before birth and is larger than moles that develop after birth.
* Determining how melanocytes in moles and LCMNs differ from normal melanocytes may increase the ability to predict whether a mole will give rise to a melanoma (a type of skin cancer)

Objectives:

* To understand how melanomas develop, by studying moles, LCMNs, and pigmented skin lesions that are suspicious for melanoma
* To develop better criteria for diagnosing melanoma, particularly by using a device called a digital dermatoscope (a special camera, connected to a computer, that takes pictures of moles when they are magnified and illuminated)

Eligibility:

* Children 5 years old or older with an LCMN
* Adults 18 years old or older with 100 or more moles larger than 2 mm in diameter and at least one 4 mm or more
* Adults 18 years old or older with a pigmented lesion suspicious for melanoma

Design:

* Patients' personal and family health history is obtained.
* Patients are examined by investigative team doctors, and several lesions are examined with a dermatoscope.
* Additional photographs of part or all of the skin surface may be taken.
* Some lesions may be biopsied.
* Additional tests or examinations may be recommended.
* Patients are followed periodically for skin or physical examinations, photography, laboratory and imaging evaluations, and possible skin biopsies.
* Children may undergo brain magnetic resonance imaging (MRI)

Conditions

  • Melanocytic Nevi
  • Acquired Melanocytic Nevi
  • Primary Cutaneous Melanoma

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    lead NIH

Eligibility

Min Age
5 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-02-03
Completion
2011-10-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00288938 on ClinicalTrials.gov