A Model for Genetic Susceptibility: Melanoma

Summary

The goal of this study is to find out if some people are more likely to get melanoma, a form of skin cancer, than others are. To do this we will compare people who have had more than one melanoma to people who have had only one melanoma and to people who are similar but who have not developed melanoma.

People respond to the environment in different ways. Some may be born with genes that make them more likely to get this type of skin cancer. Each person has many ways to repair normal damage to their genes. Specific genes may affect the repair of sun damage. Other genes affect the way the skin itself reacts to the sun. We want to find out which genes have normal changes in them and lead to different responses to exposures, such as the sun. We also want to find out if sun habits are related to the way these genes work.

Conditions

• Melanoma
• Skin Cancer

Interventions

BEHAVIORAL

Questionnaire

Exposures of interest will be measured by a self-administered personal residence, occupation and vacation calendar, a telephone interview, and by testing DNA from buccal cells and blood, when available. Standardization of diagnosis will be undertaken by review of tissue slides. Questionnaire data will be completed by interviewers. DNA will be obtained from each individual in the form of 4-6 buccal swabs

BEHAVIORAL

Questionnaire

Exposures of interest will be measured by a self-administered personal residence, occupation and vacation calendar, a telephone interview, and by testing DNA from buccal cells and blood, when available. Standardization of diagnosis will be undertaken by review of tissue slides. Questionnaire data will be completed by interviewers. DNA will be obtained from each individual in the form of 4-6 buccal swabs.

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• University of New Mexico

  collaborator OTHER

• University of North Carolina

  collaborator OTHER

• University of Michigan

  collaborator OTHER

• University of California, Irvine

  collaborator OTHER

• New South Wales Cancer Control

  collaborator UNKNOWN

• University of Tasmania

  collaborator OTHER

• Registro dei Tumori, Torino, Italy

  collaborator UNKNOWN

• British Columbia Cancer Agency

  collaborator OTHER

• Cancer Care Ontario

  collaborator OTHER

• University of Pennsylvania

  collaborator OTHER

• Memorial Sloan Kettering Cancer Center

  lead OTHER

Principal Investigators

• Arlene Orlow, PhD · Memorial Sloan Kettering Cancer Center

Eligibility

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

1999-11-30

Primary Completion

2026-07-31

Completion

2026-07-31

Countries

• United States

Study Locations