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a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure

NCT06587854 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 270

Last updated 2025-09-10

No results posted yet for this study

Summary

The goal of this observational is to study the prevalence of distinct congestion phenotypes and study their association with response to therapy and outcomes in acute heart failure patients. The main question\[s\] it aims to answer \[is/are\]:

* Primary objective: to study the prevalence of distinct congestion phenotypes
* Other objectives (including):

* Response to therapy as assessed by

* Natriuresis after 24 hours
* Rehospitalization and/or deats after 6 months
* Length of hospital stay
* Congestion at discharge
* Changes in filling pressures over time
* Relationship between liver stiffness, as assessed with Fibroscan and congestion
* Substudy: glycosaminoglycan netword and endothial glycocalyx

Participants will undergo several extra study related measurements:

* Assessment of filling pressures with ultrasound
* Ultrasound investigation of the lungs and kidneys
* Fibroscan of the liver
* Sidestream darkfield imaging sublingual
* As part of substudy GLYCO-AHF: skin biopsy to determine glycocalyx, as well as salt and water content.
* As part of substudy PREACH-AHF: the effects of peripheral venous congestion and endothelial dysfunction on a large screen of plasma proteins

Conditions

  • Acute Heart Failure

Sponsors & Collaborators

  • University Medical Center Groningen

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-05-01
Primary Completion
2028-06-30
Completion
2029-12-31

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06587854 on ClinicalTrials.gov