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The Effect of Anti-inflammatory Cryoagent on the Level of Postoperative Pain in Patients With Symptomatic Irreversible Pulpitis and Apical Periodontitis.

NCT06584188 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-04-15

No results posted yet for this study

Summary

* The aim of this study is comparative between:

1. Intra-radicular cryotherapy using cold anti-inflammatory {ketorolac tromethamine at 2-5C}.
2. Intra-radicular final flush anti-inflammatory {ketorolac tromethamine at room temperature}.
* In terms of:

C. Level of post-operative pain {POP} using a visual analog scale {VAS}. D. Level of substance P in periapical fluid will be analyzed by enzyme-linked immunosorbent assay (ELISA) kit.

Outcomes :

* Primary outcomes: Level of Post-operative pain.
* Secondary outcomes: Level of substance P expression

Conditions

  • Postoperative Pain

Interventions

DRUG

anti-inflammatory ketorolac tromethamine

* Intra- radicular anti-inflammatory {ketorolac tromethamine at room temperature}. * Intra- radicular cold anti-inflammatory {ketorolac tromethamine at 2-5C}.

Sponsors & Collaborators

  • Ain Shams University

    lead OTHER

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-04-11
Primary Completion
2026-04-12
Completion
2026-04-30

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06584188 on ClinicalTrials.gov