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Salivary Markers in Periodontal Disorders

NCT06576856 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 106

Last updated 2025-10-16

No results posted yet for this study

Summary

The swelling of the gum, or periodontitis, is the leading cause for tooth loss, and currently affects up to 65 million adults only in the United States. One of the reasons for the widespread of periodontitis is because currently there are no definitive methods to detect the onset of gum disease. This lack of foresight impedes medical professionals to enact any preventive measures before the disease already manifests itself.

We wish to expand our understanding towards the development of periodontitis by studying the expression and activity of salivary markers that have been associated with advanced stages of the disease, wherein the supporting tissues of tooth (periodontium) are already irreversibly destroyed. We hypothesize that a progressive shift in the expression of such salivary markers can indicate a change or evolution of periodontitis staging.

In specific, we seek to establish a quantifiable relationship among levels of salivary proteases called MMPs, level of metal ions in different stages varying from health to periodontitis. The overall goal of this proposal is to enhance the predictability of periodontitis, as we are currently unable to diagnose the disease until the manifestation of its clinical signs and symptoms.

Conditions

  • Periodontal Disease, Staging, Salivary Markers, Diagnosis

Interventions

OTHER

This is an observational study, no intervention is anticipated.

There is no intervention. This is an observational study.

Sponsors & Collaborators

  • Midwestern University

    lead OTHER

Principal Investigators

  • Marcela Rocha de Oliveira Carrilho, DDS, PhD · Midwestern University

Eligibility

Min Age
30 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-11-06
Primary Completion
2023-10-10
Completion
2024-10-10

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06576856 on ClinicalTrials.gov