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Diagnostic Potential of the Salivary Biomarkers to Differentiate Statuses of Periodontitis

NCT05722613 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2023-02-10

No results posted yet for this study

Summary

Periodontitis is a chronic inflammatory disease characterized by both dysbiosis of oral microbiota and proinflammatory events involving both cells and mediators from innate and adaptive immunity. These events lead to chronic inflammation of periodontal soft and hard tissues sharing many features with other chronic inflammatory diseases. These events lead to chronic inflammation of periodontal soft and hard tissues sharing many features with other chronic inflammatory diseases. Chronic inflammation is driven by various mediators, of which a significant part is attributed to the interactions within cytokine networks. While proinflammatory cytokines, including interleukin (IL) -1α, IL-1β, TNF-α, IL-6, and IL-17, contribute to acute and chronic inflammation and tissue injury, a second group with antagonist effects is formed by cytokines such as IL-10

Conditions

  • Periodontitis

Sponsors & Collaborators

  • University of Baghdad

    lead OTHER

Principal Investigators

  • zainab J Raheem, MSc · University of Baghdad

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-05-01
Primary Completion
2023-04-01
Completion
2023-06-01

Countries

  • Iraq

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05722613 on ClinicalTrials.gov