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M-I/E for Preventing VAP in Post-neurosurgical Patients

NCT06511986 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 210

Last updated 2025-03-19

No results posted yet for this study

Summary

Ventilator-associated pneumonia (VAP) is a common infection in critically ill patients, especially those with acute brain injuries, leading to increased mortality and longer ICU stays.

The mechanical insufflation/exsufflation (M-I/E) cough assist device improves outcomes in patients with neuromuscular disorders but its effects on brain-injured patients are largely unknown.

This study is conducted at a tertiary neurosurgical medical center and consists of two substudies. The prospective physiological study assessed the impact of M-I/E on hemodynamics and ICP in mechanically ventilated neurosurgical patients. The combined retrospective-prospective clinical study was performed to investigate the efficacy of M-I/E on occurence of VAP and other clinical outcomes.

Conditions

  • Ventilator Associated Pneumonia
  • Brain Injuries
  • Mechanical Insufflation-exsufflation

Sponsors & Collaborators

  • Beijing Sanbo Brain Hospital

    lead OTHER

Principal Investigators

  • Zhonghua Shi, PhD,MD · Capital Medical University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-03-04
Primary Completion
2025-01-22
Completion
2025-03-15

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06511986 on ClinicalTrials.gov