Research on Key Technologies for Risk Prediction and Precise Diagnosis and Treatment of AIS Based on Epigene-phenotype
NCT06506227 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 2000
Last updated 2024-07-17
Summary
Mining AIS biomarkers, elucidating the new mechanism of AIS pathogenicity, constructing risk prediction models, optimizing AIS precise diagnosis and treatment techniques, formulating precise diagnosis and treatment protocols and technical specifications for AIS combined with Chinese and Western medicine with independent intellectual property rights, and realizing the full coverage of Zhejiang Province by the end of 2026, so as to form the "Zhejiang experience" of AIS diagnosis and treatment.
Conditions
- Adolescent Idiopathic Scoliosis
Interventions
- BEHAVIORAL
-
Low risk experimental group
Guiding + Manipulation + Traditional Chinese Medicine
- BEHAVIORAL
-
Medium risk experimental group
Guiding + Manipulation + Traditional Chinese Medicine + Specific Exercise Therapy + Orthopedic Braces
- GENETIC
-
High risk experimental group
Guiding + Manipulation + Traditional Chinese Medicine + Specific Exercise Therapy + Orthopedic Braces + Specialized Inpatient Rehabilitation
- BEHAVIORAL
-
Control group COBB 10-20°
Specific Exercise Therapy
- BEHAVIORAL
-
Control group COBB 20-45°
Orthopedic Braces + Specific Exercise Therapy
- BEHAVIORAL
-
Control group COBB >45°
Orthopedic Braces + Specific Exercise Therapy + Recommended Surgery
- OTHER
-
Experimental group (AIS group)
Molecular marker exploration and validation
- OTHER
-
Control group (healthy control)
Molecular marker exploration and validation
- OTHER
-
Controlled follow-up before and after AIS
Construction and validation of AIS risk prediction model completed
Sponsors & Collaborators
-
The First Affiliated Hospital of Zhejiang Chinese Medical University
lead OTHER
Principal Investigators
-
Jiang Zhong, bachelor · The First Affiliated Hospital of Zhejiang Chinese Medical University
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- DOUBLE
- Model
- PARALLEL
Eligibility
- Min Age
- 10 Years
- Max Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2024-09-01
- Primary Completion
- 2026-12-31
- Completion
- 2026-12-31
Countries
- China
Study Locations
More Related Trials
-
Early Intelligent Diagnosis of Limb Deformity in Children by AI and Clinic Application
NCT04527029 ·Status: NOT_YET_RECRUITING
-
Video-based Assessment of Preschool Children's Gross Motor Development
NCT07054437 ·Status: RECRUITING
-
Using Radiation-free Ultrasound for Screening Scoliosis Among School Children in Hong Kong to Reduce Unnecessary X-ray Exposure
NCT03135665 ·Status: COMPLETED ·Phase: NA
-
Determining Developmental and Clinical Markers Affecting Urinary Function of Children With Spinal Dysraphism
NCT05962086 ·Status: UNKNOWN
-
Artificial Intelligence for Infant Motor Screening: Development and Validation
NCT05456126 ·Status: COMPLETED
-
The Relationship Between Developmental Level in Infancy and Preschool Motor Performance in Risky Infants
NCT06015347 ·Status: COMPLETED
-
A Preliminary Study on Artificial Intelligence for Infant Motor Screening
NCT04684173 ·Status: COMPLETED
-
Subtalar Joint Morphology and Foot Deformity in Cerebral Palsy
NCT04149301 ·Status: COMPLETED
-
Tilted Gaze Target Test in the Examination of Children With Superior Oblique Muscle Palsy
NCT05882552 ·Status: UNKNOWN ·Phase: NA
-
Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA)
NCT02302534 ·Status: COMPLETED ·Phase: NA
-
Idiopathic Scoliosis Progression and Sleep-disordered Breathing in Children
NCT03858244 ·Status: ACTIVE_NOT_RECRUITING
-
Early Surgical Intervention of Congenital Hemivertebra in Young Children
NCT04527406 ·Status: WITHDRAWN ·Phase: NA
-
Evaluation of Cerebrospinal Fluid Flow in Adolescent Idiopathic Scoliosis
NCT04760808 ·Status: COMPLETED
-
Predicting Cerebral Palsy in Infants With White Matter Injury Using MRI
NCT06575283 ·Status: NOT_YET_RECRUITING
-
Assessment of Hypotonia in Children With Down Syndrome
NCT05131542 ·Status: COMPLETED
-
Usefulness of Cephalometry in the Second and Third Trimester of Pregnancy in the Diagnosis of Fetal Microretrognathia
NCT04422067 ·Status: COMPLETED
-
Assessing Intellectual and Motor Outcomes in High-risk Infants
NCT06857539 ·Status: RECRUITING
-
Comparison of Intermittent Oro-Esophageal Tube Feeding in Infants With Cerebral Palsy and Dysphagia
NCT06185504 ·Status: TERMINATED ·Phase: NA
-
Interrater Reliability of Infant Motor Profile
NCT03188107 ·Status: UNKNOWN
-
Computer Aided Tool for Diagnosis of Neck Masses in Children
NCT05187923 ·Status: UNKNOWN
-
Summary of Infants Weighing 500 Grams or Less
NCT05322980 ·Status: COMPLETED
-
Skull Bon Variations in Patient with Congenital Unilatral Choanal Atresia
NCT06890442 ·Status: NOT_YET_RECRUITING
-
Development of Dysphagia Evaluation Via Video Analysis Based on Deep Learning Method in Neonates and Infants and Correlation Between the Evaluation and the Development
NCT05204966 ·Status: UNKNOWN ·Phase: NA
-
AI-assisted cEEG Diagnosis of Neonatal Seizures in Neonatal Intensive Care Unit
NCT04991779 ·Status: WITHDRAWN
-
Urinary Markers of Detrusor Overactivity in Spina Bifida Patients
NCT02852317 ·Status: COMPLETED