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Subtalar Joint Morphology and Foot Deformity in Cerebral Palsy

NCT04149301 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 23

Last updated 2024-02-29

No results posted yet for this study

Summary

Cerebral palsy (CP) is a major cause of disability. Many children with CP develop foot deformities as they grow and these can become painful, adversely affecting their quality of life. The research team has previously studied foot morphology and biomechanics, including analysis of the subtalar joint and has successfully located the joint axis from MRI scans.

In this project 25 children will be recruited (15 children with CP and 10 unimpaired control subjects). Each child will attend for a single visit, when they will undergo an MRI scan (with the foot loaded and unloaded) to measure the morphology of the ankle and foot, in particular the subtalar axis alignment. This has not been done before in CP.

Each child will have an instrumented gait analysis and musculoskeletal modelling techniques will be used to study the biomechanical action of the external ground reaction force and internal muscle forces. The potential of these forces to rotate the subtalar joint and deform the foot will be assessed, resulting in new insights into potential mechanisms of foot deformity.

The children will then be categorised to identify those most at risk, leading to personalised screening measures and treatment strategies in the future.

Conditions

  • Cerebral Palsy

Interventions

DIAGNOSTIC_TEST

3D gait analysis

Children will have their walking measured in the gait laboratory to record their kinematics and kinetics along with electromyography (EMG) from key muscle groups.

DIAGNOSTIC_TEST

MRI scan

The children will have two MRI scans taken - one with the foot loaded and one with no load applied.

Sponsors & Collaborators

  • Keele University

    collaborator OTHER

  • Imperial College London

    collaborator OTHER

  • University of Oxford

    collaborator OTHER

  • University of Aberdeen

    collaborator OTHER

  • Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust

    lead OTHER_GOV

Eligibility

Min Age
7 Years
Max Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-04-01
Primary Completion
2023-11-01
Completion
2023-12-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04149301 on ClinicalTrials.gov