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Evaluation of Cerebrospinal Fluid Flow in Adolescent Idiopathic Scoliosis

NCT04760808 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 72

Last updated 2024-09-19

No results posted yet for this study

Summary

Adolescent Idiopathic Scoliosis (AIS) is the most frequent spinal deformity in adolescence, but its etiology remains unknown. Recent publications suggest a link between ciliopathy and AIS. More specifically a modification of the cerebro-spinal fluid (CSF) flow by ciliary dysfunction could be at the origin of a scoliotic deformity.

This study aims to compare the CSF flow measured by magnetic resonance imaging (MRI) in an AIS group and a control group.

Conditions

  • Adolescent Idiopathic Scoliosis

Interventions

DIAGNOSTIC_TEST

Baseline Clinical Examination

Evaluations of Postural control; Subjective postural vertical; Subjective visual vertical; Verticality perception

RADIATION

Initial 3T MRI of the Brain and Spine

Non-injected CSF flow MRI

DIAGNOSTIC_TEST

6-month Follow-up Clinical Examination

Evaluations of Postural control; Subjective postural vertical; Subjective visual vertical; Verticality perception

RADIATION

6-month Follow-up 3T MRI of the Brain and Spine

Non-injected CSF flow MRI

Sponsors & Collaborators

  • SSR pédiatrique Marc Sautelet

    collaborator UNKNOWN

  • Lille Catholic University

    lead OTHER

Principal Investigators

  • Jean-François CATANZARITI, MD · SSR Marc Sautelet, France

Eligibility

Min Age
12 Years
Max Age
17 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-02-10
Primary Completion
2022-05-04
Completion
2022-05-04

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04760808 on ClinicalTrials.gov