Predicting Cerebral Palsy in Infants With White Matter Injury Using MRI

Summary

The goal of this study is to determin the MRI features associated with cerebral palsy and to develop prediction models of pediatric disorders by combining MRI with artificial intelligence.

The main questions it aims to answer are:

* How to achieve features on conventional MRI associated with cerebral palsy?
* How to predict the risk of cerebral palsy in infants aged 6 to 2 years based on conventional MRI and deep learning? Researchers will compare characteristics of periventricular white matter injury with cerebral palsy to those without cerebral palsy.

Participants will be asked to provide MRI data, clinical diagnoses information, and follow-up outcomes.

Conditions

• Cerebral Palsy
• Periventricular White Matter Abnormalities

Interventions

OTHER

No intervention will be performed in this cohort study

Deep learning classification models will be used for automatic prediction of cerebral palsy. Machines will be used to assist doctors in cerebral palsy risk evaluation.

Sponsors & Collaborators

• The First Affiliated Hospital of Henan University of Traditional Chinese Medicine

  collaborator OTHER

• Shenzhen Children's Hospital

  collaborator OTHER_GOV

• Zunyi Medical College

  collaborator OTHER

• Wuxi Women's & Children's Hospital

  collaborator OTHER

• Shanxi Provincial Maternity and Children's Hospital

  collaborator OTHER

• Chengdu Medical College

  collaborator OTHER

• First Affiliated Hospital of Xinjiang Medical University

  collaborator OTHER

• Baoji Central Hospital

  collaborator OTHER

• Xian Children's Hospital

  collaborator OTHER_GOV

• Guangzhou Women and Children's Medical Center

  collaborator OTHER

• Third Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• Henan Provincial People's Hospital

  collaborator OTHER

• First Affiliated Hospital Xi'an Jiaotong University

  lead OTHER

Principal Investigators

• Jian Yang, Ph.D.,M.D · First Affiliated Hospital Xi'an Jiaotong University

Eligibility

Min Age

6 Months

Max Age

2 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-09-01

Primary Completion

2025-12-31

Completion

2025-12-31

Countries

• China

Study Locations