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Biomarkers Associated With Temporomandibular Disorders in Patients With Rheumatoid Arthritis

NCT06488937 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 92

Last updated 2024-07-05

No results posted yet for this study

Summary

The goal of this observational study is to determinate temeporomandibular disorders (TMDs) and levels of biomarkers in 30 rheumatoid arthritis patients and 30 healthy controls.

Aims are:

* to determine TMDs symptoms in both groups using a validated Reasearch Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) protocol
* to determine levels of interleukin-4 (IL-4), interleukin-18 (IL-18) and interferon-gamma (IFN-γ) in saliva and serum in RA patients and control group
* to determine levels of biomarkers (Ca, Mg, P, AST,ALT,ALP,GGT,urate) in serum of RA patients and control group
* investigate the correlation between cytokines level in saliva and serum
* to determine the effect of TMDs on cytokine and biomarker levels Participants will be clinicaly examined by DMD in accordance with the RDC/TMD guidelines to receive both Axis I and Axis II diagnoses. After examination participants would be asked for saliva and blood sample.

Conditions

Sponsors & Collaborators

  • University of Rijeka Faculty of Dental Medicine

    collaborator UNKNOWN

  • Josip Juraj Strossmayer University of Osijek

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-11-01
Primary Completion
2022-05-30
Completion
2025-02-28

Countries

  • Croatia

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06488937 on ClinicalTrials.gov