Investigating Multimodally Endothelial Dysfunction in Ocular and Systemic Disease

Summary

To explore the distribution of retinal vasculature parameters in patients with different subtypes of cardiovascular and ocular disease.

Conditions

• Kidney Diseases
• Diastolic Heart Failure
• Small Vessel Disease
• Glaucoma

Interventions

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Optical coherence tomography(-angiography) OCT(A)

OCTA is a non-invasive diagnostic tool capable of generating cross-sectional coupes of the retina and choroid. Novel algorithms allow to render a 3-dimensional model of the ocular microcirculation based merely on the motion contrast of the circulating blood.

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Fundus pictures

Visucam (Zeiss), Topcon NW8 fundus camera, NFC 600 (Crystalvue)

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DVA 3.0

IMEDOS GmbH

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Hyperspectral retinal images

Ximea SNm4x4 hyperspectral snapshot camera

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SphygmoCor

Sphygmocor Excell

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Sphygmomanometer

For the measurement of the blood pressure.

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Blood sample

For both routine cardiovascular health biomarkers as well as genetic markers (DNA, mRNA, miRNA).

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Skin biopsy

Spatial proteomics and transcriptomics for endothelial function.

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Neuropsychological examination

Moca, Stroop color word test, concept shifting test, COWAT, (R)AVLT, Beck depression inventory, GDS

Sponsors & Collaborators

• Universitaire Ziekenhuizen KU Leuven

  lead OTHER

Principal Investigators

• Ingeborg Stalmans, MD, PhD · Universitaire Ziekenhuizen KU Leuven

Study Design

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-07-06

Primary Completion

2024-12-31

Completion

2024-12-31

Countries

• Belgium

Study Locations