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Retinal Microvascularization and Cardiovascular Disease

NCT03551717 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 155

Last updated 2020-05-27

No results posted yet for this study

Summary

The main objective of this study is to investigate whether there are links between the blood vessels of the retina as a whole and heart and/or vascular diseases (cardiovascular diseases).

The arteries and veins of the retina are, like the large vessels of the human body (aorta, coronary, cerebral arteries), exposed to the complications of hypertension, diabetes, obesity, dyslipidemia (abnormal blood lipid profile) or tobacco. Several studies have shown that changes in retinal vessels (microvascularization) generally occur several years before damage to large peripheral vessels (macrovascularization). The study of the vessels of the retina is now possible thanks to simple and non-invasive examinations of photographs (not creating any lesion). They allow a painless evaluation of the vessels in the retina.

Ultimately, if this study is conclusive, the patient's cardiovascular risk could be evaluated simply by analysis of the vessels of the retina.

The study is being conducted in the ophthalmology and cardiology departments of Dijon University Hospital. In total, the investigators wish to include approximately 510 patients who present cardiovascular risk factors (255 low risk patients recruited in the ophthalmology department and 255 high risk patients hospitalized in the cardiology department).

All patients participating in the study will be asked to visit the ophthalmology department for a complete examination of the retina.

Conditions

  • High Cardiovascular Risk Patients
  • Low Cardiovascular Risk Patients

Interventions

OTHER

Optical Coherence Tomography angiography

At the inclusion visit for all patients and at M3 only for 50 patients.

OTHER

Fundus

At the inclusion visit for all patients and at M3 only for 50 patients.

OTHER

cardiac ultrasound scan

Only for 50 patients, 3 months after the initial cardiovascular event

Sponsors & Collaborators

  • Centre Hospitalier Universitaire Dijon

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-03-14
Primary Completion
2019-04-19
Completion
2019-04-19

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03551717 on ClinicalTrials.gov