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Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury

NCT06480838 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 130

Last updated 2025-07-01

No results posted yet for this study

Summary

Cognitive impairment after moderate to severe traumatic brain injury (msTBI) not only significantly affects the quality of life in individuals with msTBI, but also increases the possibility of late-life dementia. The goal of this study is to determine whether acute (\< 1 week) cerebrovascular injury and its recovery within the first year postinjury measured by cerebral autoregulation and brain perfusion are associated with cognitive outcome at 12 months after msTBI. The results from this study will improve our understanding of cerebrovascular contributions to cognitive decline related to TBI and provide critical data to inform the development of strategies based on vascular mechanisms to improve cognition and prevent neurodegeneration after msTBI.

Conditions

  • Traumatic Brain Injury With Loss of Consciousness
  • Brain Injury Traumatic Severe
  • Brain Injury Traumatic Moderate
  • TBI (Traumatic Brain Injury)
  • TBI

Sponsors & Collaborators

  • Albert Einstein College of Medicine

    collaborator OTHER

  • Texas Health Resources

    collaborator OTHER

  • Institute for Exercise and Environmental Medicine

    collaborator UNKNOWN

  • National Institute of Neurological Disorders and Stroke (NINDS)

    collaborator NIH

  • University of Texas Southwestern Medical Center

    lead OTHER

Principal Investigators

  • Kan Ding, MD · UT Southwestern Medical Center

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-01
Primary Completion
2027-03-31
Completion
2028-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06480838 on ClinicalTrials.gov