Head Computed Tomography for Predicting Neurological Outcome After Cardiac Arrest

Summary

The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) joint guidelines for post-resuscitation care recommend a multimodal approach to prognostication of neurological outcome.

However, head computed tomography (CT) which is commonly used for predicting long-term neurological outcome after cardiac arrest has not yet been examined prospectively in a clinical trial.

The primary purpose of the TTM-2 CT-substudy is to prospectively investigate and compare various methods of diagnosing generalized oedema on CT after cardiac arrest and it´s ability to predict long-term neurological outcome.

Conditions

• Heart Arrest, Out-Of-Hospital
• Computed Tomography
• Unconsciousness
• Neurologic Deficits

Interventions

DIAGNOSTIC_TEST

CT

Head computed tomography on patients still unconscious 48 hours after cardiac arrest.Visual evaluation of generalized oedema ("eye-balling"). Manual and automated measurement of the differentiation of gray and white matter (GWR) using circular regions of interest (ROI).

Sponsors & Collaborators

• Region Skane

  collaborator OTHER

• Charite University, Berlin, Germany

  collaborator OTHER

• Halmstad County Hospital

  collaborator OTHER

• Sahlgrenska University Hospital

  collaborator OTHER

• Karlstad Central Hospital

  collaborator OTHER

• Medical University Innsbruck

  collaborator OTHER

• University Hospital of Wales

  collaborator OTHER

• Hopital Lariboisière

  collaborator OTHER

• Nantes University Hospital

  collaborator OTHER

• University Hospital, Linkoeping

  collaborator OTHER

• Lund University

  lead OTHER

Principal Investigators

• Marion Moseby-Knappe, MD · Lund University and Skane University Hospitals Sweden

• Tobias Cronberg, MD, PhD · Lund University and Skane University Hospitals Sweden

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-11-18

Primary Completion

2022-12-31

Completion

2023-03-12

Countries

• Sweden

Study Locations