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Neural Circuit Mechanism of Inflammatory Bowel Disease Combined With Depression

NCT06471894 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2024-06-25

No results posted yet for this study

Summary

The goal of this observational study is to understand the effects of gut microbiota dysbiosis treatment in patients with inflammatory bowel disease (IBD) combined with depression. The main question it aims to answer is:

Does fecal microbiota transplantation (FMT) improve depression symptoms in IBD patients by altering GABA levels in the medial prefrontal cortex?

Participants already undergoing fecal microbiota transplantation (FMT) as part of their regular medical care for IBD and comorbid depression will undergo regular assessments of GABA levels, gut microbiota, and depression symptoms for the duration of the study.

Conditions

  • Inflammatory Bowel Diseases

Interventions

RADIATION

Magnetic resonance imaging scanning

Perform brain diffusion imaging, magnetic resonance spectroscopy, and functional magnetic resonance imaging scans on all individuals

DRUG

FMT Protocol

Treatment of disease groups (UC and CD) using prepared fecal microbiota transplantation solution

Sponsors & Collaborators

  • LanZhou University

    lead OTHER

Principal Investigators

  • Jun Wang, Doctor · The Second Hospital & Clinical Medical School, Lanzhou University

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-07-01
Primary Completion
2024-07-01
Completion
2027-12-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06471894 on ClinicalTrials.gov