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Effects of Transcranial Direct Current Stimulation Associated With Physical Exercise: a Metaplasticity Study

NCT02263092 · Status: UNKNOWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2015-02-26

No results posted yet for this study

Summary

This study aims to understand metaplasticity through the association of transcranial direct current stimulation (tDCS) and physical exercise. For this purpose, the study will be separate in 2 phases: in the first phase the aim is verify the effects of physical exercise on cortical excitability. After this 1st phase two intensities of physical exercise will be chosen for the second phase. In the 2nd phase, subjects will undergo to anodal, cathodal and sham tDCS plus physical exercise.

Conditions

  • Metaplasticity
  • Healthy Subjects

Interventions

BEHAVIORAL

Physical exercise

The intensity of physical exercise will be determine by the maximum heart rate (max HR) using the formula (220 - age). For the high intensity, the intensity will between 79-95% xx% of maxHR; moderate intensity, 64-76% of maxHR; mild intensity, 57-63% of maxHR. Furthermore, during the physical exercise the heart rate will be continuous evaluate by the POLAR and the rate perceived scale will be register in each 3 minutes by the modified Borg scale

DEVICE

tDCS

Current will be applied by a DC stimulator (NeuroConn, Germany) using a pair of saline-soaked sponge electrodes (surface 35 and 36cm²). tDCS will be applied to Cz and Oz according to International 10-20 EEG system. In the anodal tDCS, the anode will be placed in Cz and cathode in Oz. In the cathodal tDCS the inverse position will be done. Parameters of current intensity and duration (dose) used were 2 mA stimulation intensity for 20 minutes with current ramping up and down of 10 seconds each.For sham, the same position of anodal tDCS will be assumed, however, current duration is only 30 seconds, with current ramping up and down of 10 seconds each. Moreover, the electrostimulation device is automatically turned off without patient's perception. Thus, patients experience early sensations (mild to moderate tingling) in stimulation site without inducing effect. Moreover, after each tDCS session, patients will answer adverse effects questionnaire.

BEHAVIORAL

Rest

15 or 30 minutes seat without move the legs

Sponsors & Collaborators

  • Universidade Federal de Pernambuco

    lead OTHER

Principal Investigators

  • Kátia Monte-Silva, PHD · Applied Neuroscience Laboratory, Universidade Federal de Pernambuco

Study Design

Allocation
RANDOMIZED
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-02-28
Primary Completion
2015-02-28
Completion
2015-07-31

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02263092 on ClinicalTrials.gov