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Effects of Vagal Nerve Stimulation on Leg Muscle Activity and Posture in Parkinson's Disease

NCT07226284 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 75

Last updated 2026-02-13

No results posted yet for this study

Summary

This study is designed to better understand the mechanisms contributing to impaired activation of leg muscles in people with Parkinson's disease (PD) and to test if stimulation of a nerve at the neck can improve muscle activation, walking and balance.

Conditions

  • PARKINSON DISEASE (Disorder)
  • Parkinson's Disease (PD)

Interventions

DEVICE

Vagal nerve stimulation

The gammaCore non-invasive vagus nerve stimulator (nVNS) is a hand-held portable device that is used to apply electrical stimulation to the vagus nerve via two electrodes.

OTHER

No intervention

No nVNS is applied in the baseline experiment. Sham nVNS is applied for experiment two

Sponsors & Collaborators

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
76 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-02-10
Primary Completion
2029-01-31
Completion
2029-01-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07226284 on ClinicalTrials.gov